Congential varicella syndrome (CVS) and Neonatal infection

Etiology:

Mother contraction of Varicella zoster virus (chicken pox) during the first two trimesters of pregnancy.

Symptoms (in X % of cases):

skin lesions in dermatomal distribution (76%)

neurologic defects (60%)

eye diseases (51%)

skeletal anomalies (49%)

Prognosis:

  • 30% of infants born with these lesions died in the first months of life.
Prevention:
Vaccination of women of child-bearing years who do not already possess immunity to the virus.
Neonatal Varicella zoster
Treatment and Management:
  1. Acyclovir
  2. Zoster immunoglobulins
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