Castleman’s disease (angiofollicular hyperplasia)
a rare disorder characterized by non-cancerous growths (tumors) that may develop in the lymph node tissue at a single site or throughout the body.
The neoplasm is an angiofollicular hyperplasia – a follicular hyperplasia of lymph nodes with abnormally increased interfollicular vascularity.
Herpes Simplex virus 8, HSV-8, has been associated with Kaposi’s sarcoma, Primary Effusion lymphoma and multicentric Castleman’s Disease.
Castleman’s is characterized by a hyperproliferation of cytokine producing B cells.