Castleman’s disease (angiofollicular hyperplasia)

a rare disorder characterized by non-cancerous growths (tumors) that may develop in the lymph node tissue at a single site or throughout the body.

The neoplasm is an angiofollicular hyperplasia – a follicular hyperplasia of lymph nodes with abnormally increased interfollicular vascularity.

Etiology:

Herpes Simplex virus 8, HSV-8, has been associated with Kaposi’s sarcoma, Primary Effusion lymphoma and multicentric Castleman’s Disease.

Castleman’s is characterized by a hyperproliferation of cytokine producing B cells.

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