Zostavax Vaccine Preparation

Vaccine preparation information:

Lyzophilized strain of live attenuated varicella zoster virus initially obtained from a child with naturally occurring varicella zoster virus (VZV).

This strain was inoculated into human embryonic lung cell cultures.

The line was then adapted to and inoculated and propagated in guinea pig cell cultures. It was finally propagated in diploid human cell cultures.

Vaccine dose information:

single dose: 0.65mL

contains a minimum of 19,400 PFU (plaque-forming units) of VZV.

Each dose also contains:

  1. 31.16 mg of sucrose
  2. 15.58 mg of hydrolyzed porcine gelatin
  3. 3.99 mg of sodium chloride
  4. 0.62 mg of monosodium L-glutamate
  5. 0.57 mg of sodium phosphate dibasic
  6. 0.10 mg of potassium phosphate monobasic
  7. 0.10 mg of potassium chloride
  8. residual components of MRC-5 cells including DNA and protein
  9. trace quantities of neomycin and bovine calf serum.

The product contains no preservatives.

Injection:

Subcutaneous, preferably in upper arm.

Adverse reactions (table shown from clinical trail)

Adverse Experience
ZOSTAVAX
(N = 3345)
%
Placebo
(N = 3271)
%
Injection Site
Erythema†
33.7
6.4
Pain/tenderness†
33.4
8.3
Swelling†
24.9
4.3
Hematoma
1.4
1.4
Pruritus
6.6
1.0
Warmth
1.5
0.3
Systemic
Headache
1.4
0.8

RxList. (2006). Zostavax drug description. Retrieved February 25, 2011 from http://www.rxlist.com/zostavax-drug.htm

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: