Pulmonary Fibrosis

A condition characterized by deposition of fibrous tissue in the lung. It decreases lung compliance and results in a restrictive ventilatory defect as seen on pulmonary function testing. A chronic lung inflammation with progressive scarring of the alveolar walls that can lead to death.

Physiology:

Fibrosis, build up of tissue, changes the surface area of lung tissue available for gas exchange. Decreased gas exchange at the lungs results in impaired oxygenation of the body tissues.

Etiology:

Prolonged inflammation, infection or disease of the lungs results in activation of an immune response. Immune cells trigger fibroblasts that replaced damaged lung cells with tough, fibrous cells creating scar tissue or fibrosis in the place of the former healthy lung tissue.

Manifestations:

  1. Dyspnea
  2. Dry cough
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