a genetic neurological disorder.
also named ‘happy puppet’ syndrome as affected individuals typically have a happy, sociable personality.
mutation on chromosome 15.
occurs in 1 in 15,000 live births.
- severe motor and intellectual retardation
- frequent jerky limb movements and flapping of the arms and hands
- absence of speech
- frequent smiling
- outbursts of laughter
- an unusual facies (facial appearance) – characterized by macrostomia (large mouth), a large jaw and open-mouthed expression, and a great propensity for protruding the tongue (tongue thrusting).
Angelman Syndrome. 2010. MedicineNet.com. retrieved May 10, 2010 from http://www.medicinenet.com/angelman_syndrome/glossary.htm