Malignant hyperthermia (malignant hyperpyrexia due to anaesthesia)

a rare life-threatening hereditary condition in which certain drugs used for general anesthesia (e.g., halothane) cause high body temperatures and muscle rigidity.

Manifestations:

  1. intense muscle contractions
  2. a high fever
  3. tachycardia
  4. tachypnea
  5. hypotension
  6. decreased cardiac output leading to heart failure
  7. increased metabolic rate
  8. metabolic and respiratory acidosis

Management and Treatment:

  1. Dantrolene – a skeletal muscle relaxant
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